Which serotonin receptor antagonist is commonly used to prevent severe nausea and vomiting post-operatively?

Ondansetron is commonly used as a serotonin receptor antagonist to prevent severe nausea and vomiting, especially in post-operative settings. It works by blocking the 5-HT3 serotonin receptors in the central nervous system and the gastrointestinal tract. This action helps to reduce the feeling of nausea and prevent vomiting, making it particularly effective in patients undergoing surgery or receiving chemotherapy.

While other serotonin receptor antagonists like Granisetron, Palonosetron, and Dolasetron are also effective in managing nausea and vomiting, Ondansetron has been one of the most widely used and studied in the context of post-operative care. Its specific approval and extensive clinical use in these scenarios contribute to its reputation as a go-to agent for preventing post-operative nausea and vomiting.