When educating a client about ondansetron, which adverse effect should the nurse address?

Ondansetron, a commonly used antiemetic agent, is effective in preventing nausea and vomiting, particularly in patients undergoing chemotherapy or surgery. However, one of its notable adverse effects that should be discussed is diarrhea.

This side effect concerns the gastrointestinal response to the medication, but it is important to recognize that ondansetron primarily works by blocking serotonin receptors in the brain and gastrointestinal tract, which can lead to alterations in normal bowel movements. While it is often associated with reducing nausea, it can paradoxically stimulate some patients' gastrointestinal activity resulting in diarrhea.

Addressing diarrhea as a potential adverse effect is crucial for patient education, as it can impact the patient's comfort, hydration status, and overall quality of life. Additionally, patients should be informed about recognizing symptoms of dehydration or significant gastrointestinal disturbance that may warrant medical attention. Understanding this side effect empowers clients to be proactive in managing their responses to the medication and enhances their overall treatment experience.