What education should be provided to clients regarding the use of promethazine?

Promethazine is an antihistamine that is often used as an antiemetic and for its sedative properties. One of the important side effects to educate clients about is the potential for urinary retention. This occurs because promethazine can have anticholinergic effects, which may inhibit the normal function of bladder contraction, leading to difficulties in urination in some individuals. Clients should be made aware of this possible side effect, especially if they have a history of urinary issues or are taking other medications that may exacerbate this concern.

In contrast to the other options, which do not accurately reflect the appropriate education regarding promethazine, option B highlights a significant aspect of the medication's profile. While promethazine can be taken with or without food, and its use does not relate to treating hypertension, the potential for urinary retention is a pertinent concern that clients should be aware of for their safety and well-being.